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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study, including recruitment and consent, adherence and the use routinely available equipment.

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A practical trial that employs different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for pragmatic trials to be able to prove their validity and reduces bias in the results. However too much heterogeneity could cause problems with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and 프라그마틱 불법 체험 (linked site) achieve maximum external validity. They are typically ordered by policymakers and practitioners to help inform their decisions. They can also be a great way to identify the cause-effect relationship between the intervention and its effects. They should, however, not be used to replace explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic study that includes the recruitment, design, and delivery of the intervention, and follow-up.

There is a positive increase in the number of pragmatic trials that have been published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more sensitive to the issue of pragmatics. It is important to remember that the majority were conducted in primary-care settings.